
PROPOFOL
Unidade Curricular de Toxicologia Mecanística
2013/2014
Ana Teresa Melanda Alves
Rúben Filipe Monteiro Calaia
Bibliografia
1. DrugBank: Propofol [Acedido em 11/05/2014]. Available from: http://www.drugbank.ca/drugs/DB00818
2. Diprivan (Propofol) Injectable Emulsion USP [Acedido em 17/05/2014]. Available from: http://www.drugs.com/pro/diprivan.html.
3. Silva A, Sousa E, Palmeira A, Amorim P, Guedes de Pinho P, Ferreira DA. Interaction between hydroxyethyl starch and propofol: computational and laboratorial study. Journal of biomolecular structure & dynamics. 2013.
4. Fodale V, La Monaca E. Propofol infusion syndrome: an overview of a perplexing disease. Drug safety : an international journal of medical toxicology and drug experience. 2008;31(4):293-303.
5. Diedrich DA, Brown DR. Analytic reviews: propofol infusion syndrome in the ICU. Journal of intensive care medicine. 2011;26(2):59-72.
6. Balasubramaniam B, Park GR. Sexual hallucinations during and after sedation and anaesthesia. Anaesthesia. 2003;58(6):549-53.
7. Sebel PS, Lowdon JD. Propofol: a new intravenous anesthetic. Anesthesiology. 1989;71(2):260-77.
8. Julien F. Biebuy MB, D. Phil. Propofol. An update on its clinical use. Anesthesiology. 1994;81:1005-43.
9. Schicher M, Polsinger M, Hermetter A, Prassl R, Zimmer A. In vitro release of propofol and binding capacity with regard to plasma constituents. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik eV. 2008;70(3):882-8.
10. Katzung BG. Basic & Clinical Pharmacology. 12 th ed2012.
11. Rudolph U, Mohler H. Analysis of GABAA receptor function and dissection of the pharmacology of benzodiazepines and general anesthetics through mouse genetics. Annual review of pharmacology and toxicology. 2004;44:475-98.
12. Franks NP. Molecular targets underlying general anaesthesia. British journal of pharmacology. 2006;147 Suppl 1:S72-81.
13. Adelman JP, Maylie J, Sah P. Small-conductance Ca2+-activated K+ channels: form and function. Annual review of physiology. 2012;74:245-69.
14. Kozinn J, Mao L, Arora A, Yang L, Fibuch EE, Wang JQ. Inhibition of glutamatergic activation of extracellular signal-regulated protein kinases in hippocampal neurons by the intravenous anesthetic propofol. Anesthesiology. 2006;105(6):1182-91.
15. MHA- Metro Health Anesthesia [Acedido em 29/01/2014]. Available from: http://www.anesthesiawiki.net/metrohealthanesthesia/MHAnes/edu/ivanes/propofol5.htm.
16. Gepts E. Pharmacokinetic concepts for TCI anaesthesia. Anaesthesia. 1998;53 Suppl 1:4-12.
17. Gold MI, Abraham EC, Herrington C. A controlled investigation of propofol, thiopentone and methohexitone. Canadian journal of anaesthesia = Journal canadien d'anesthesie. 1987;34(5):478-83.
18. Trapani G, Altomare C, Liso G, Sanna E, Biggio G. Propofol in anesthesia. Mechanism of action, structure-activity relationships, and drug delivery. Current medicinal chemistry. 2000;7(2):249-71.
19. Court MH, Duan SX, Hesse LM, Venkatakrishnan K, Greenblatt DJ. Cytochrome P-450 2B6 is responsible for interindividual variability of propofol hydroxylation by human liver microsomes. Anesthesiology. 2001;94(1):110-9.
20. Loryan I, Lindqvist M, Johansson I, Hiratsuka M, van der Heiden I, van Schaik RH, et al. Influence of sex on propofol metabolism, a pilot study: implications for propofol anesthesia. European journal of clinical pharmacology. 2012;68(4):397-406.
21. Choong E, Loryan I, Lindqvist M, Nordling A, el Bouazzaoui S, van Schaik RH, et al. Sex difference in formation of propofol metabolites: a replication study. Basic & clinical pharmacology & toxicology. 2013;113(2):126-31.
22. Gandhi M, Aweeka F, Greenblatt RM, Blaschke TF. Sex differences in pharmacokinetics and pharmacodynamics. Annual review of pharmacology and toxicology. 2004;44:499-523.
23. Gan TJ, Glass PS, Sigl J, Sebel P, Payne F, Rosow C, et al. Women emerge from general anesthesia with propofol/alfentanil/nitrous oxide faster than men. Anesthesiology. 1999;90(5):1283-7.
24. Schuttler J, Ihmsen H. Population pharmacokinetics of propofol: a multicenter study. Anesthesiology. 2000;92(3):727-38.
Bibliografia de figuras:
Figura 1: http://www.ecologiamedica.net/2012/11/suplementos-e-fitoterapicos-e-o-risco.html (Acedido em 23/05/2014)
Figura 4: http://www.drmarkmoore.com/Medications/Diprivan_Diprovan_Propofol/diprivan_diprovan_propofol_product_presentation.htm (Acedido em 10/05/2014);
Figura 6: http://www.dentalnews.at/was-ist-propofol/ (Acedido em 17/05/2014);
